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Smooth muscle cell phenotypic diversity

Web12 Apr 2024 · Lin et al. found that circ_0021155 was upregulated in ox-LDL-treated human aorta vascular smooth muscle cells (HASMCs), and overexpression of circ_0021155 promoted HASMC proliferation and migration with a decrease in the protein levels of α-actin, calponin, and smooth muscle myosin heavy chain (SMMHC) as well as an increase in … Web1 Jan 2024 · Smooth muscle cell phenotypic diversity. Arterioscler Thromb Vasc Biol, 39 (2024), pp. 1715-1723. CrossRef View in Scopus Google Scholar. 3. ... Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.

Potential of PCSK9 as a new target for the management of LDL …

Web15 Jan 2016 · Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J 2007;15(3):100–8. pmid:17612668 . View Article PubMed/NCBI … Web5 Jun 2024 · Vascular smooth muscle cells (VSMC) are stromal cells of the blood vessels and their differentiation is thought to be essential during atherosclerosis. Cathelicidin-related antimicrobial peptides (CRAMP) are suggested to play a role in the development of atherosclerosis. Even so, the relationship of CRAMP and VSMC remains unclear. The … fairweather lodge san antonio texas https://omnimarkglobal.com

Potential of PCSK9 as a new target for the management of LDL …

Web23 hours ago · Smooth Muscle Cell Phenotypic Diversity. [Role of intercellular communications in hepatic differentiation and carcinogenesis]. KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role inAtherosclerotic Plaque Pathogenesis; Phenotypic changes to vascular smooth muscle cells induced by oxidant-modified extracellular matrix Web20 Nov 2024 · A common event in CVD pathophysiology is the switch of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic phenotype. Interestingly, oxidative stress is a major contributor to this phenotypic switch. ... Van Eys, G. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth. Heart J. 2007, … Web12 hours ago · Using single-cell RNA sequencing, researchers identified 12 atherosclerosis-associated cell states and found that Vcam1+ smooth muscle cell state contributed the most to the genetic heritability of coronary artery disease. A hybrid polygenic risk score (PRS) that considers cell-type-specific regulatory elements demonstrated improved … fairweather lodge iowa city iowa

14–3-3 protein regulation of excitation–contraction coupling

Category:Different vasodilator responses of human arms and legs - PMC

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Smooth muscle cell phenotypic diversity

Targeting the Phenotypic Diversity of Vascular Smooth Muscle Cells …

Web31 Mar 2015 · Vascular smooth muscle cells (vSMCs) are one of the major components of the aortic wall which can be divided into quiescent contractile and activated synthetic … Web11 Apr 2024 · My research focuses on the impact of circulating miRNAs and mitochondria on different diseases. Through my work I am uncovering the impact of how circulating miRNAs can be used as biomarkers and ...

Smooth muscle cell phenotypic diversity

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Web13 Apr 2024 · Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding tumor microenvironment (TME), composed of a myriad of cell types and … WebAlthough the primary role of vascular smooth muscle cells (SMCs) is contraction, they exhibit extensive phenotypic diversity and plasticity during normal development, during …

Web1 May 2004 · These findings of heterogeneous vascular responses in both humans and animals suggest phenotypic differences in vascular endothelium and smooth muscle … WebSimilarly, autophagy genes are almost universally downregulated by MSX1 overexpression in endothelial cells, but are largely unchanged in smooth muscle cells. It has been previously shown in a mouse model of peripheral arterial disease, that during arterial remodeling, functional role of MSX1 and its expression linked to BMP signaling in SMCs is different …

WebThe resulting phenotypic diversity of smooth muscle cells appears to be a function of innate genetic programmes and environmental cues, which include biochemical factors, extracellular matrix components, and physical factors such as stretch and shear stress. Web25 Jul 2024 · Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and blood distribution, as well as maintaining the structural integrity of the blood …

WebThe Effect of Statin Medications on Muscle Performance study reported that subjects treated with atorvastatin 80 mg daily had more muscle symptoms than those treated with …

Web26 Nov 2024 · Vascular smooth muscle cells (VSMCs) are one of the most abundant cells in vessel walls and have emerged as key players in disease progression. New technologies, … fairweather ltdWebIon channels are proteins in the cell membrane that allow the cells to communicate with the exterior world. The amazing thing about ion channels is that their function can be studied in real time, using techniques like patch-clamp and fluorescence. This is what we do in the lab. We try to understand how some types of ion channels work and how are they regulated by … fairweather lodge seneca paWebA method has been developed to induce and retain a contractile phenotype for vascular smooth muscle cells, as the first step towards the development of a biomimetic blood … do iris and barry get marriedWeb11 Dec 2016 · Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative … do iris bloom the first year plantedWebMorphological and molecular changes in blood vessels ascribed to elevated pressure consist of endothelial damage, neointima formation, activation of inflammatory cascades, … do iris flowers bloom multiple timesWebThis diversity strongly impairs bioproduction as the presence of low-producer or slow-grower cells reduces overall yields. However, the universal phenomenon of subpopulations emergence has been largely overlooked, especially in … fairweather murderWebAbstract. Aim: Smooth muscle cell (SMC) phenotypic switching in the aortic media may play a critical role in the pathogenesis of thoracic aortic dissection (TAD). However, few … fairweather road redlynch