Diethylene glycol metabolism

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August undefined, 2024

WebEthylene glycol is widely used as antifreeze (concentration range: 80%–99%) or de-icing solutions (concentration range: 3%–40%) for cars, boats, and aircraft. It is also used in … WebApr 14, 2024 · Glycol has a strong dissolving capability but it is easily to be oxidized to toxic metabolic oxalic acid and therefore can’t be widely used as a solvent. The ethylene glycol can be supplemented to the hydraulic fluid and can be used for preventing the erosion of oil-based hydraulic fluid on the rubber of the system; the water-based hydraulic ...

Ethylene Glycol - Metabolic Activation - European …

WebNov 28, 2024 · From 12 to 48 hours, ethylene glycol metabolites produce severe anion gap metabolic acidosis with compensatory hyperventilation. The acidosis results primarily from an increase in glycolic acid, although glyoxylic, oxalic, and lactic acids also contribute in small part. Calcium oxalate crystals are deposited in the brain, lungs, kidneys, and heart. WebFeb 27, 2024 · Diethylene glycol was once used as a vehicle for the drug sulphanilamide and when used for this it caused some 76 deaths. ... The mechanism of toxicity of ethylene glycol involves metabolism, but … mid 90s caravan transmission cooler

Inhibition of Metabolism of Diethylene Glycol Prevents Target …

WebNov 1, 1991 · The disposition of carbon-14-labeled diethylene glycol (DEG) was determined in rats after oral, iv, and dermal administration, and in dogs after oral … WebAug 14, 2014 · Metabolism. Diethylene glycol monoethyl ether is metabolized by cytochrome P450 enzymes and in particular by alcohol dehydrogenase. In an adult volunteer given a single oral dose of 11.2 mmol diethylene glycol monoethyl ether, 68% of the dose was eliminated with the urine as 2-(2-ethoxyethoxy)acetic acid. ... new smyrna florida hospital

Diethylene Glycol - an overview ScienceDirect Topics

Renal Toxicity Caused by Diethylene Glycol: an Overview

WebJul 29, 2011 · The ethylene glycol (EG) metabolites glycolic acid (GA) and oxalic acid (OA) were not detected in any of these studies. In DEG-intoxicated patients, oxalate crystals have also not been found in the urine or kidney tissues ( Alfred et al., 2005; Brophy et al., 2000; Okuonghae et al., 1992 ). WebThe most common cause of tachypnea is uncompensated metabolic acidosis. Ethylene glycol poisoning through ingestion can cause noncardiogenic pulmonary edema and ARDS. Ethylene glycol poisoning can cause dysrhythmias and heart failure. Ethylene glycol toxicity is characterized by an osmolal gap and metabolic acidosis with an elevated … mid 90s chinosWebDiethylene glycol ethyl ether Formula : C 6 H 14 O 3 Molecular weight : 134.17 g/mol CAS-No. : 111-90-0 EC-No. : 203-919-7 Component Classification Concentration diethylene glycol monoethyl ether <= 100 % SECTION 4: First aid measures 4.1 Description of first-aid measures If inhaled After inhalation: fresh air. In case of skin contact new smyrna events this weekend

"WebNov 1, 2007 · Diethylene and ethylene glycols are both metabolized by alcohol and aldehyde dehydrogenases to produce toxic metabolites. Both glycols produce coma, … " - Diethylene glycol metabolism

Diethylene glycol metabolism

Opinion on diethylene glycol monobutyl ether (DEGBE)

WebJun 14, 2015 · This glycolic acid cannot be metabolised in an acid-scavenging way, like lactate or ketones. Thus, this acidosis is "bicarbonate-resistant". More bicarbonate must be added in order to buffer the excessive number of hydrogen ions present in the patient, so that H 2 O and CO 2 may be generated. WebJan 1, 2001 · The role of ADH in the in vivo metabolism of diethylene glycol is less clear than for the other homologues. In the present study, detectable oxidation of diethylene glycol was observed at 82 mM (the lowest con- centration tested). Thus, metabolism of diethylene glycol may be at least partially catalyzed by ADH in vivo.

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WebSep 20, 2024 · Diethylene glycol (DEG) is nephrotoxic, potentially resulting in high morbidity and mortality. Its main nephrotoxic by-product is diglycolic acid (DGA). WebOften colored fluorescent yellow-green when used in automotive antifreeze. DESCRIPTION: Ethylene glycol is a useful industrial compound found in many consumer products. Examples include antifreeze, hydraulic brake fluids, some stamp pad inks, ballpoint pens, solvents, paints, plastics, films, and cosmetics. It can also be a pharmaceutical vehicle.

WebDiethylene glycol (DEG), a solvent and chemical intermediate, can produce an acute toxic syndrome, the hallmark of which is acute renal failure due to cortical tubular … WebDec 21, 2012 · Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. DEG is used …

WebJun 14, 2015 · Ethylene glycol is a traditional cause of high anion gap metabolic acidosis, and occupies the "E" spot in the MUDPILES mnemonic. The chief cause of metabolic … WebAbstract. Introduction: Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. In addition to its use in a wide …

WebJul 1, 2024 · Diethylene glycol is an organic liquid compound with the chemical structure: CH 2 OHCH 2 OCH 2 CH 2 OH. It is a colorless, odorless, hygroscopic liquid with a …

Webcoingestants (eg, ethanol inhibits diethylene glycol metabolism). Oliguric or anuric acute kidney failure with metabolic acidosis is typical. Death can occur 2 to 7 days after the onset of anuria in untreated patients; the other patients usually remain dialysis dependent. Renal ultrasound shows enlarged or swollen kidneys new smyrna fl real estateWebSep 26, 2024 · National Center for Biotechnology Information new smyrna fl newsWebDiethylene glycol (DEG) is a colorless, virtually odorless liquid with a sweet taste typically used in antifreeze solutions and as a solvent for many products. When … mid 90s full movie 123moviesWebThe metabolite was isolated and characterized by 13C-NMR to be 2- (hydroxy) ethoxyacetic acid (HEAA). Confirmation of identity was provided by synthesis of HEAA and comparison of its NMR spectra and chromatographic behavior with those of the metabolite. new smyrna florida real estateWebDiethylene glycol (DEG) is a sweet-tasting, colorless, nonodoriferous, hygroscopic liquid commonly used in the commercial preparation of antifreeze, brake fluid, cigarettes, and … mid 7 transportationWebJan 1, 2024 · Methanol, ethylene, or diethylene glycol. Excessive, chronic acetaminophen ingestion. Salicylate toxicity. Alcoholic ketoacidosis. All of the above can potentially contribute to metabolic acidosis. A search of the patient’s home did not reveal a source of methanol or either ethylene or diethylene glycol. mid90s free steamWebDiethylene glycol is rapidly absorbed and distributed to the kidneys, brain, liver, spleen, and adipose tissue. The kidneys receive most of the DEG. The volume of distribution of … mid90s free online