Cisplatin anticancer mechanism

WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new … WebA New Molecular Mechanism of Cisplatin Resistance A very recent investigation demonstrated a new mechanism by which the oncoprotein c-Myc enables cancer cells …

Nephrotoxicity of anticancer treatment Nephrology Dialysis ...

WebApr 29, 2024 · In order to overcome cisplatin-resistance, seven cyclometalated ruthenium ( II) complexes were synthesized with a varying degree of fluorine substitution, for use as anticancer agents. A cytotoxicity assay testified that the complexes possessed a more cytotoxic effect than cisplatin towards the cisplatin-resistant cell line A549R. WebApr 10, 2024 · The current study focuses on the Pd (II) and Pt (II) trinuclear chelates with spermidine (Pd 3 Spd 2 and Pt 3 Spd 2) and aims to evaluate its putative anticancer activity towards cisplatin-resistant TNBC cells (MDA-MB-231/R), as compared to cisplatin-sensitive TNBC (MDA-MB-231), by assessing the (i) antiproliferative activity, (ii) … react pass parent ref to child https://omnimarkglobal.com

Bonn researchers elucidate a mechanism underlying cisplatin …

WebCisplatin (DDP) has been a significant tumor chemotherapy against various solid malignant tumors, including lung adenocarcinoma, since it was approved by the Food and Drug Association in 1978.7Platinum chemotherapy drugs, represented by DDP, are antitumor agents. WebOct 6, 2016 · Multiple mechanisms including tubular epithelial cell toxicity, vasoconstriction in the renal microvasculature and proinflammatory effects contribute to renal dysfunction following exposure to cisplatin. The mechanism of nephrotoxicity is associated with a chloride ion at the cis position of the drug. WebApr 12, 2024 · The combination of the chemotherapy drugs cisplatin and paclitaxel has long been the standard treatment for women with advanced or recurrent endometrial cancer. But treatment options for these two groups of patients have changed recently, largely because of advances in immunotherapy. react pass onclick to child

Biochemical mechanisms of cisplatin cytotoxicity - PubMed

Category:Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

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Cisplatin anticancer mechanism

Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

WebMar 15, 2011 · Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased DNA repair. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. Web1152 rows · Jun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. …

Cisplatin anticancer mechanism

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WebJun 20, 2024 · Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of … WebDiverse molecular mechanisms underlying cisplatin resistance including decreased cellular uptake, increased cellular efflux, enhanced cellular inactivation, and increased cellular tolerance to DNA damage have been described for different cancer types.

WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA … WebCisplatin (Anti-cancer Drug) 1 of 22 Cisplatin (Anti-cancer Drug) Nov. 19, 2024 • 5 likes • 3,784 views Download Now Download to read offline Education The Slide is about the Anti-cancer Drug (alkylating agent) Cisplatin. AsthaNeupane Follow Advertisement Advertisement Recommended Cisplatin tsclayton 18.8k views • 16 slides Platinum analogs

WebApr 29, 2024 · The drug-resistance of cancer cells has become a major obstacle to the development of clinical drugs for chemotherapy. In order to overcome cisplatin … WebJul 1, 2024 · Action mechanism of cisplatin anticancer activity. Cisplatin may also induce cell apoptosis from cell membrane [57]. The type II transmembrane protein and Fas …

WebA deep knowledge of the biochemical mechanisms, which are triggered in the tumor cell …

WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … how to stay awake during examWeb2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … how to stay awake during churchWeb2 days ago · Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli. react pass setstate as propsWebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism by which resistance is reported to develop is a reduction in … react pass setstate to child typescriptWebNov 2, 2024 · Among other cancers, cisplatin is used as a first-line treatment for: leukemia lymphoma breast cancer testicular cancer ovarian cancer head and neck cancer cervical … how to stay awake all night at workWebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response … react pass ref to another componentWebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … how to stay awake for 20 hours