WebFurthermore, circSHOC2 regulates SIRT1 expression by sponging miR-7670-3p. Transfection with a siRNA-7670-3p and incubation with circSHOC2 extracellular vesicles attenuated ischemia-induced neuronal apoptosis in vivo and in vitro, while silencing SIRT1 reversed the protective effects of exosomal circSHOC2 on hypoxic brain neurons. WebApr 1, 2024 · CircSHOC2 significantly upregulated: CircSHOC2/miR-7670-3p/SIRT1 axis: Circshoc2 inhibits neuronal apoptosis and alleviates neuronal damage: Chen W et al. Common RNA-SEQ data of human IS focus tissues and controls: hsa-Circ 0078299 and FXN — Neuroprotection and brain recovery: Silva P W et al. There were 170 AIS …
Brain Sciences Free Full-Text A Novel Perspective on Ischemic ...
WebMar 22, 2024 · Interestingly, in another study conducted by Chen et al. (2024c) they found that circSHOC2 inhibited OGD-induced neuronal apoptosis by promoting autophagy in ischemic brain injury, suggesting a protective role of circSHOC2 and autophagy in ischemic stroke. The discrepancies may be due to the different circRNAs and cell types used in … WebOct 1, 2000 · Request PDF Targeting Gene Transfer Selectively to Vascular Endothelial Cells Using Peptides Isolated by Phage Display: Implications for Development of Gene Therapy in Hypertension 75 Current ... cypress head homes for sale parkland
CircSHOC2 Knockdown Alleviates High Glucose-Induced …
WebSep 1, 2016 · Request PDF Abstract P158: Cullin3 Regulated Endothelial Function by Modulating eNOS Activity Pseudohypoaldosteronism type II (PHAII) patients expressing dominant negative cullin3 mutations ... WebOct 18, 2024 · CircSHOC2 (circ_0092670) is transcribed from the SHOC2 gene and shows significantly increased expression in ischemic preconditioning astrocyte exosomes (IPAS-EXOs). SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several … WebCircular RNA circSHOC2 (hsa_circ_0092670) is located at chromosome 10, whose genomic length is 13,454, with abundant expression in the cerebellum, occipital lobe, frontal cortex, and parietal lobe. A recent study from Chen’s team declared that circular RNA circSHOC2 in ischemic-preconditioned astrocyte-derived exosomes (IPAS-EXOs) could ... binary discrete memoryless channel